I suck at drawin' with a mouse, but I think that's mainly because I'm left-handed (my right-hand is useless, although it can catch a frisbee decently...). But I totally agree with Asher; with enough practice, anything can be a great tool!
(PS Asher: I would definitely recommend Wacom tablets; they're pretty expensive, but the quality's great~ )
Thanks for the Drama CD translation, Blade! I've been meanin' to listen to them ack~