Guilty Gear Isuka is the tenth installment of the Guilty Gear series. While the gameplay remained almost the same as in previous titles, the game introduced a four-player battle mode and three new characters.
- GGI/Sol Badguy
- GGI/Ky Kiske
- GGI/Chipp Zanuff
- GGI/Axl Low
- GGI/Millia Rage
- GGI/Anji Mito
- GGI/Jam Kuradoberi
- GGI/Robo-Ky II
A.B.A, Robo-Ky MK. II, Leopaldon and the Zako-Dan make their debut to the cast of Guilty Gear.
A.B.A fights with her giant key-axe, Paracelsus. While her initial movement is slow and lacks an air dash, her second stance gives her faster movement and powerful attacks, at the cost of her own health.
Robo-Ky MK. II is an expansion on the original Robo-Ky, now mimicking the entire cast's moves, not just Ky.
Leopaldon is the final boss of Isuka.
The Zako-Dan are a group of 3 minions, each a different playstyle. Considered to be the joke characters of the game.