Usually, it is recommended that Weiss is played on point given her lackluster assists with only her 6P being truly reliable. Unless she ends her combo with a sweep, she'll need an assist to safely set up her glyphs.
Tips and Tricks
Always set up glyphs and position yourself so they're spread out, even using the enhanced version. This will open up more options for Weiss in choosing how to attack and make herself more unpredictable.